Zetpil™ Leucine Suppository


  • Leucine is the only dietary amino acid that has the capacity to stimulate muscle protein synthesis as well as reducing muscle loss.
  • Leucine can create a tremendous boost to high-intensity athletic regimens aimed at building muscle and reducing post-exercise recovery time.
  • Leucine supplementation can help turn on the body’s switch to build muscle and spare muscle when dieting.*
  • May help prevent chronically-ill patients or those with age- or disease-related muscle loss.]
    * These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


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Zetpil™ Suppository Advantage

Zetpil™ delivers nutrition via the rectum with the use of suppositories that have a unique, all- natural formulated base that has revolutionized not only this mode of delivery, but also the ability to obtain nutrients in a far more efficacious method.  These suppositories are a result of combining natural ingredients with a non-irritating, rapid melting (5-6 minutes), readily absorbable (superior retention), antioxidant base material (free radical scavenging ability) and delivers the nutrients directly into the bloodstream in less than 20 minutes in a highly effective manner. Oral supplements are exposed to the hazards of stomach acid, digestive enzymes, food-related breakdown, first pass metabolism, and other bioavailability issues in the gastro-intestinal system.

Additionally, many raw materials simply have a very low bioavailability, and only achieve around 10% or less (commonly <1%) absorption rates, even if the patient is in optimal health condition. Compromised health, age, or certain conditions that result in an inability to take oral nutrients often preclude these patient populations from obtaining the necessary nutrition to stay healthy which often exacerbates chronic health issues. 

Zetpil™ suppositories are a NOW solution to delivering the necessary nutrients to patients, on a daily basis, that is both easy, comfortable and cost effective. The safety and noticeable effectiveness of these products will far outweigh any initial hesitation you have regarding this mode of delivery.

What is Leucine?

Leucine is an essential branched chain amino acid, but one the body cannot synthesize and therefore it must be ingested, usually as a component of proteins. It is the most abundant of the three branched chain amino acids in muscles, and therefore acts as the primary “fuel” for our muscular system.  Leucine is the only dietary amino acid that has the capacity to stimulate muscle protein synthesis and also potently activates signaling pathways responsible for regulating cell growth and tissue building.

It is the level of amino acids in the blood that directly boosts protein synthesis in muscles.  Leucine, in particular, is the most capable of stimulating protein synthesis as well as reducing muscle loss.  Consequently, leucine supplementation is not only advantageous for athletes, but also to prevent age- or disease-related muscle loss.

Supplement Facts

Serving Size:  1 suppository

Servings per Container:  60

Each Zetpil™ Leucine contains the following ingredients:
**A proprietary bend of Leucine and Methyl Hydroxy Chalcone Polymers.
Suppository Base: The base is a proprietary combination of excipients of plant and fruit butters, vegetable acids, medium chain triglycerides, phospholipids, lecithin, vegetable starches, cellulose, oligosaccharide derivatives and polysaccharide derivatives.

This product is contraindicated in individuals with a known hypersensitivity to phospholipids, or any of the listed ingredients.

If you choose to use this product as a rectal suppository, it is highly recommended you attempt to clear your bowels prior to inserting it to avoid premature evacuation.  To facilitate insertion it is recommended you moisten the product by passing it under a stream of cool water or use a personal lubricant. When used as a suppository, this product requires 15-20 minutes retention to ensure the complete absorption of the bioactive ingredients. This suppository can be inserted in any position. Although not required, if inserted while lying on one’s side, consider remaining in the supine position for 1-3 minutes following insertion.(Always insert flat end of suppository first).


Although safe for children, this product should be kept out of the reach of children.

Do not use if the suppositories are open or damaged.

As with any nutrient if you are pregnant or breastfeeding, seek the advice of a health care provider before using this product.

Individuals that have chosen to take this product as part of a personal nutrient program have overwhelmingly chosen to utilize this product as a rectal suppository or as a vaginal pessary.  However, this product can also be taken safely by mouth. If one chooses to take this product orally, then this product may be considered a dietary supplement in accordance with current FDA guidelines.

Disclaimer: These statements have not been evaluated by the FDA. This product is a Federal Food, Drug, and Cosmetic Act compliant combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA.  In accordance with FDA regulations, when taken orally, this product may be considered a dietary supplement as defined by section 201(ff) of the Act, 21 U.S.C. § 321(ff). Also, this product consists ONLY of a combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA. Therefore, this product cannot be considered a drug as defined in section 201(g)(1) of the Act, 21 U.S.C. § 321(g)(1). This product is not intended to affect the structure or function of the body and is not intended for use in the diagnosis, cure, mitigation, treatment or prevention of disease in man. Any nutritional suggestions and research regarding this product are provided for informational purposes only, and are not intended to diagnose, treat, cure or prevent disease nor should any information provided be used as a  substitute for sound medical advice.


Leucine-enriched essential amino acids attenuate muscle soreness and improve muscle protein synthesis after eccentric contractions in rats

Amino Acids 2015 Jun; 47(6):1193-201

Kato H, et al


Impact of leucine supplementation on exercise training induced anti-cardiac remodeling effect in heart failure mice

Nutrients 2015 May 15; 7(5):3751-66

de Moraes WM, et al


Leucine-enriched essential amino acid supplementation during moderate steady state exercise enhances postexercise muscle protein synthesis

Am J Clin Nut 2011 Sep; 94(3):809-18

Pasiakos SM, et al


Dietary Leucine – An Environmental Modifier of Insulin Resistance Acting on Multiple Levels of Metabolism

PLoS One 2011; 6(6): e21187

Yazmin Macotela, et al


Chronic leucine supplementation improves glycemic control in etiologically distinct mouse models of obesity and diabetes mellitus

Nutrition & Metabolism 2010, 7:57

Kaiying Guo, et al


The efficacy of a β-hydroxy-β-methylbutyrate supplementation on physical capacity, body composition and biochemical markers in elite rowers: a randomised, double-blind, placebo-controlled crossover study

J Int Soc Sports Nutr 2015; 12: 31

Krzysztof Durkalec-Michalski, et al


Additional information

Weight 8.0 oz
Dimensions 6 × 3 × 9 in