Zetpil™ Genistein HPM SR Suppository


Serving Size:  1 suppository

Servings per Container:  30

Each Genistein 98% HPM SR (Sustained Release) contains the following ingredients: 

370 mgs of 98% concentration of certified pharmaceutical grade 4’5,7-trihydroxyisoflavone (Genistein)

Homeopathic ingredient: Genista Tinctoria – 60X

Suppository Base: The base is a proprietary combination of excipients of plant and fruit butters, vegetable acids, medium chain triglycerides, phospholipids, lecithin, vegetable starches, cellulose, oligosaccharide derivatives and polysaccharide derivatives.

Out of stock


Zetpil™ Suppository Advantage

Zetpil™ delivers nutrition via the rectum with the use of suppositories that have a unique, all- natural formulated base that has revolutionized not only this mode of delivery, but also the ability to obtain nutrients in a far more efficacious method.  These suppositories are a result of combining natural ingredients with a non-irritating, rapid melting (5-6 minutes), readily absorbable (superior retention), antioxidant base material (free radical scavenging ability) and delivers the nutrients directly into the bloodstream in less than 20 minutes in a highly effective manner. Oral supplements are exposed to the hazards of stomach acid, digestive enzymes, food-related breakdown, first pass metabolism, and other bioavailability issues in the gastro-intestinal system.

Additionally, many raw materials simply have a very low bioavailability , and only achieve around 10% or less (commonly <1%) absorption rates, even if the patient is in optimal health condition. Compromised health, age, or certain conditions that result in an inability to take oral nutrients often preclude these patient populations from obtaining the necessary nutrition to stay healthy which often exacerbates chronic health issues. 

Zetpil™ suppositories are a NOW solution to delivering the necessary nutrients to patients, on a daily basis, that is both easy, comfortable and cost effective. The safety and noticeable effectiveness of these products will far outweigh any initial hesitation you have regarding this mode of delivery.

What makes the Zetpil™ Genistein SR Different?

Zetpil™ Genistein HPM SR is unique because it represents the marriage of science and reality.  By embracing the physical properties of genistein (low oral bioavailability and high enzymatic metabolism), the researchers and scientists at Zetpil™ conceived that an alternative delivery method may increase the levels of genistein one could achieve over a longer period of time.  Based on research-proven concepts of absorption-enhancing natural compounds, excipients, therapeutically effective dosages and state-of-the-art production methods, Zetpil™ has formulated a genistein product which is cost-effective, safe, non-competitive, avoids enzymatic breakdown in the stomach and liver and is patient-friendly. 

A Sustained Release (SR) mechanism has been used to help maintain the optimal dosage over a longer period of time.  Also, a homeopathic dilution of 60X of Genista Tinctoria has been added to enhance the efficacy of this product and as such may be considered homeopathic in nature, as indicated by the “HPM” (HomeoPathic Medicine) after the product name.

What is Genistein?

Genistein (4′, 5, 7-trihydroxyisoflavone) is one of the major soy isoflavones and has been extensively studied over the past few decades for its health-promoting properties and its correlation to lower incidences of breast and prostate cancer in Asian countries where soy intake is high. Genistein has also been shown to be an anti-oxidant, chemopreventative and anti-inflammatory compound.

What is the problem with Oral Genistein?

Genistein has moderate absorption in the Gastrointestinal (GI) tract, but then suffers from extensive metabolism resulting in its low oral bioavailability overall  After oral administration, Genistein is mainly present as its metabolites (i.e. glucuronides and sulfates).  Pharmacokinetic studies show that genistein has less than 15% absolute bioavailability in humans when administered orally. Taken together, these facts may explain the large variations of results seen in clinical trials with Genistein.



The Therapeutic Potential of Genistein

Genistein has been clinically studied to determine not only its health-promoting values, but across various disease states to identify its disease-fighting properties. Genistein has shown tremendous promise in cancer prevention, heart disease, inflammatory conditions, weight gain and bone health.

*Has not been evaluated by the FDA


Genistein has been shown to:

  • improve blood pressure,*
  • reduce thickness in the walls of major heart vessels like the  aorta*, and
  • lower cholesterol levels, including LDL levels which can cause the build-up of plaque and lead to heart disease (atherosclerosis)* .http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3181048/


“Diabetic retinopathy (DR) is a common complication affecting approximately 50% of diabetic patients within 15 years after onset of the disease” and there are no current curative treatments. Recent studies suggest that genistein can act as an “innovative anti-inflammatory agent and counteract retinal inflammation associated with diabetes”.*  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2965567/


Genistein has been proven to be a novel cancer preventative, or chemopreventative, compound*. Genistein has shown beneficial effects on reducing serum PSA (prostate specific antigen). Genistein may also protect against the development of hormone-based cancers (ie: breast and prostate), as well as be synergistic with current cancer treatments (ie: chemotherapy).* http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010305/ 


Scientific evidence has shown that genistein is able to both prevent age-related bone loss as well as restore bone density and quality, particularly in post-menopausal women.  Genistein has shown better responses than alendronate (Fosamax), raloxifene and estradiol, without the side effects.*

Genistein may be able to:

Supplement Facts

Serving Size:  1 suppository

Servings per Container:  30

Each Genistein 98% HPM SR (Sustained Release) contains the following ingredients: 

370 mgs of 98% concentration of certified pharmaceutical grade 4’5,7-trihydroxyisoflavone (Genistein) – 370 mgs

Homeopathic ingredient: Genista Tinctoria – 60X

Suppository Base: The base is a proprietary combination of excipients of plant and fruit butters, vegetable acids, medium chain triglycerides, phospholipids, lecithin, vegetable starches, cellulose, oligosaccharide derivatives and polysaccharide derivatives.

This product is contraindicated in individuals with a known hypersensitivity to phospholipids, any of the listed ingredients.

If you choose to use this product as a rectal suppository, it is highly recommended you attempt to clear your bowels prior to inserting it to avoid premature evacuation.  To facilitate insertion it is recommended you moisten the product by passing it under a stream of cool water or use a personal lubricant. When used as a suppository, this product requires 15-20 minutes retention to ensure the complete absorption of the bioactive ingredients. This suppository can be inserted in any position. Although not required, if inserted while lying on one’s side, consider remaining in the supine position for 1-3 minutes following insertion. (Always insert flat end of suppository first).


  • Although safe for children, this product should be kept out of the reach of children.
  • Do not use if the suppositories are open or damaged.
  • As with any nutrient if you are pregnant or breastfeeding, seek the advice of a health care provider before using this product.

Individuals that have chosen to take this product as part of a personal nutrient program have overwhelmingly chosen to utilize this product as a rectal suppository or as a vaginal pessary.  However, this product can also be taken safely by mouth. If one chooses to take this product orally, then this product may be considered a dietary supplement in accordance with current FDA guidelines.

The addition of a homeopathic dilution of 60x has been added to enhance the efficacy of this product. Therefore, this product may also be considered to be homeopathic in nature. Accordingly, these products comply with FDA regulations regarding the formulation and production of homeopathic products. 

Disclaimer: These statements have not been evaluated by the FDA. This product is a Federal Food, Drug, and Cosmetic Act compliant combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA.  In accordance with FDA regulations, when taken orally, this product may be considered a dietary supplement as defined by section 201(ff) of the Act, 21 U.S.C. § 321(ff).

Also, this product consists ONLY of a combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA. Therefore, this product cannot be considered a drug as defined in section 201(g)(1) of the Act, 21 U.S.C. § 321(g)(1). This product is not intended to affect the structure or function of the body and is not intended for use in the diagnosis, cure, mitigation, treatment or prevention of disease in man. Any nutritional suggestions and research regarding this product are provided for informational purposes only, and are not intended to diagnose, treat, cure or prevent disease nor should any information provided be used as a  substitute for sound medical advice.


There are almost 9,000 free peer-reviewed scholarly articles about genestein at the U.S. National Library of Medicine (www.ncbi.com).  We encourage anyone looking for more scientific and medical information to follow this link.http://www.ncbi.nlm.nih.gov/pmc/?term=genestein

Inhibition of cancer cell invasion and metastasis by genistein

Cancer Metastasis Rev Sep 2010; 29(3): 465–482

Janet M. Pavese, et al


Chemoprevention of Prostate Cancer: Soy Isoflavones and Curcumin

Korean J Urol 2012 Oct; 53(10): 665–672

Shigeo Horie, et al


The novel targets for anti-angiogenesis of genistein on human cancer cells

Biochem Pharmacol 2005 Jan 15; 69(2):307-18

Su SJ, et al


Genistein attenuates retinal inflammation associated with diabetes by targeting of microglial activation

Mol Vis 2010 Oct 8; 16:2033-42

Ibrahim AS, et al


Genistein inhibits osteoclastic differentiation of RAW 264.7 cells via regulation of ROS production and scavenging

Int J Mol Sci 2014 Jun 12; 15(6):10605-21

Lee SH, et al


The Bone-Protective Effect of Genistein in the Animal Model of Bilateral Ovariectomy: Roles of Phytoestrogens and PTH/PTHR1 Against Post-Menopausal Osteoporosis

Int J Mol Sci 2014 Jun 12; 15(6):10605-21

Qing Miao, et al


Genistein suppresses LPS-induced inflammatory response through inhibiting NF-κB following AMP kinase activation in RAW 264.7 macrophages

PLoS One 2012; 7(12):e53101

Ji G, et al


Bioavailability and Pharmacokinetics of Genistein: Mechanistic Studies on its ADME

Anticancer Agents Med Chem 2012 Dec; 12(10): 1264–1280

Zhen Yang, et al


Inhibitory Effect of Genistein on PLC/PRF5 Hepatocellular Carcinoma Cell Line

Int J Prev Med 2015; 6: 54

Mehdi Nikbakht Dastjerdi, et al


Additional information

Weight 4.1 oz
Dimensions 6 × 1.5 × 9 in