Zetpil™ Honokiol 300 SR Suppository


  • Powerful antioxidant against free radical damage
  • May help normalize blood glucose levels*
  • May support reducing anxiety and seizures by modulating GABA receptors*
  • May help activate PPAR, which has been clinically shown to be helpful in treating Alzheimer’s disease (AD)*
  • May be a safe adjunctive therapy during cancer treatments*
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.



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Zetpil Suppository Advantage

Zetpil™ delivers nutrition via the rectum with the use of suppositories that have a unique, all- natural formulated base that has revolutionized not only this mode of delivery, but also the ability to obtain nutrients in a far more efficacious method.  These suppositories are a result of combining natural ingredients with a non-irritating, rapid melting (5-6 minutes), readily absorbable (superior retention), antioxidant base material (free radical scavenging ability) and delivers the nutrients directly into the bloodstream in less than 20 minutes in a highly effective manner. Oral supplements are exposed to the hazards of stomach acid, digestive enzymes, food-related breakdown, first pass metabolism, and other bioavailability issues in the gastro-intestinal system.

Additionally, many raw materials simply have a very low bioavailability , and only achieve around 10% or less (commonly <1%) absorption rates, even if the patient is in optimal health condition. Compromised health, age, or certain conditions that result in an inability to take oral nutrients often preclude these patient populations from obtaining the necessary nutrition to stay healthy which often exacerbates chronic health issues.

Zetpil™ suppositories are a NOW solution to delivering the necessary nutrients to patients, on a daily basis, that is both easy, comfortable and cost effective. The safety and noticeable effectiveness of these products will far outweigh any initial hesitation you have regarding this mode of delivery.

What is Honokiol?

Honokiol is a small molecule polyphenol from Magnolia grandiflora which has been shown to have antioxidative, anti-inflammatory, anti-tumor, anti-diabetic, anti-microbial, anti-neurodegeneration, and anti-depressant properties.  Honokiol easily moves across the blood brain barrier making it an attractive compound for brain cancers and neurodegenerative diseases. 

Honokiol has also been shown to have potent analgesic (pain relief) properties.  Its anti-inflammatory properties have shown tremendous benefit for inflammatory disorders like rheumatoid arthritis, psoriasis, inflammatory bowel disease and asthma.  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765942/

Supplement Facts

Serving Size:  1 suppository

Servings per Container:  30

Each Honokiol 300 SR (Sustained Release) contains the following ingredients: 

300 mgs in a blend of a lower concentration 2-(4-hydroxy-3-prop-2-enyl-phenyl)- 4-prop-2-enyl-phenol  and the purest and highest concentration of 98%  2-(4-hydroxy-3-prop-2-enyl-phenyl)- 4-prop-2-enyl-phenol from the bark Magnolia grandiflora tree.

This blend was created to insure both comfort as well as efficacy.

Suppository Base: The base is a proprietary combination of plant and fruit butters, medium chain triglycerides, phospholipids, lecithin and arrow root starch.

This product is contraindicated in individuals with a known hypersensitivity to phospholipids, or any of the listed ingredients.

Due to the nature of the product suppositories cannot be returned or exchanged.

If you choose to use this product as a rectal suppository, it is highly recommended you attempt to clear your bowels prior to inserting it to avoid premature evacuation.  To facilitate insertion it is recommended you moisten the product by passing it under a stream of cool water or use a personal lubricant. When used as a suppository, this product requires 15-20 minutes retention to ensure the complete absorption of the bioactive ingredients. This suppository can be inserted in any position. Although not required, if inserted while lying on one’s side, consider remaining in the supine position for 1-3 minutes following insertion. (Always insert flat end of suppository first).


  • Although safe for children, this product should be kept out of the reach of children.
  • Do not use if the suppositories are open or damaged.
  • As with any nutrient if you are pregnant or breastfeeding, seek the advice of a health care provider before using this product.

Individuals that have chosen to take this product as part of a personal nutrient program have overwhelmingly chosen to utilize this product as a rectal suppository. However, this product can also be taken safely by mouth. If one chooses to take this product orally, then this product may be considered a dietary supplement in accordance with current FDA guidelines.

Disclaimer: These statements have not been evaluated by the FDA. This product is a Federal Food, Drug, and Cosmetic Act compliant combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA.  In accordance with FDA regulations, when taken orally, this product may be considered a dietary supplement as defined by section 201(ff) of the Act, 21 U.S.C. § 321(ff).

Also, this product consists ONLY of a combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA. Therefore, this product cannot be considered a drug as defined in section 201(g)(1) of the Act, 21 U.S.C. § 321(g)(1). This product is not intended to affect the structure or function of the body and is not intended for use in the diagnosis, cure, mitigation, treatment or prevention of disease in man. Any nutritional suggestions and research regarding this product are provided for informational purposes only, and are not intended to diagnose, treat, cure or prevent disease nor should any information provided be used as a  substitute for sound medical advice.      



Anti-Inflammatory Bioactivities of Honokiol through Inhibition of Protein Kinase C, Mitogen-Activated Protein Kinase, and the NF-κB Pathway To Reduce LPS-Induced TNFα and NO Expression

Journal of Agricultural and Food Chemistry 2010 58 (6), 3472-3478

Louis Kuoping Chao, et al


Honokiol: a novel natural agent for cancer prevention and therapy

Curr Mol Med Dec 2012; 12(10): 1244–1252

Sumit Arora, et al


Honokiol, a Multifunctional Antiangiogenic and Antitumor Agent

Levi E. Fried and Jack L. Arbiser

Antioxid Redox Signal 2009 May; 11(5): 1139–1148


Honokiol is a potent scavenger of superoxide and peroxyl radicals

Dikalov S, et al

Biochem Pharmacol 2008 Sep 1; 76(5):589-96


Cachexia and Oxidative stress in cancer: an innovative therapeutic management

Mantovani G, et al

Curr Pharm Des 2012 May 23


Honokiol Inhibits Epidermal Growth Factor Receptor Signaling and Enhances the Antitumor Effects of Epidermal Growth Factor Receptor Inhibitors

Rebecca J. Leeman-Neill, et al

Clinical Cancer Research 2010; May 1; 16(9):2571-9


Honokiol and magnolol as Multi-functional Antioxidative Molecules for Dermatologic Disorders

Jui-Lung Shen, et al

Molecules 2010 15 6452-6465


Additional information

Weight 4.1 oz
Dimensions 6 × 1.5 × 9 in