Zetpil™ Seratone Suppositories


  • Strong clinical evidence for the use of 5-HTP for depression, anxiety and panic attacks, insomnia, migraine headaches, obesity, and obsessive compulsive disorders (OCD).*
  • May help alleviate stress levels and pain associated with Fibromyalgia*
  • Unlike other 5-HTP-based products, Zetpil™ Seratone can deliver a therapeutic dosage of this important serotonin precursor directly into the bloodstream, bypassing oral absorption issues and the unwanted side effects (nausea, diarrhea or vomiting) often associated with oral ingestion of 5-HTP (5-Hydroxytryptophan).*
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

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Zetpil™ Suppository Advantage

Zetpil™ delivers nutrition via the rectum with the use of suppositories that have a unique, all- natural formulated base that has revolutionized not only this mode of delivery, but also the ability to obtain nutrients in a far more efficacious method.  These suppositories are a result of combining natural ingredients with a non-irritating, rapid melting (5-6 minutes), readily absorbable (superior retention), antioxidant base material (free radical scavenging ability) and delivers the nutrients directly into the bloodstream in less than 20 minutes in a highly effective manner. Oral supplements are exposed to the hazards of stomach acid, digestive enzymes, food-related breakdown, first pass metabolism, and other bioavailability issues in the gastro-intestinal system.

Additionally, many raw materials simply have a very low bioavailability , and only achieve around 10% or less (commonly <1%) absorption rates, even if the patient is in optimal health condition. Compromised health, age, or certain conditions that result in an inability to take oral nutrients often preclude these patient populations from obtaining the necessary nutrition to stay healthy which often exacerbates chronic health issues.

Zetpil™ suppositories are a NOW solution to delivering the necessary nutrients to patients, on a daily basis, that is both easy, comfortable and cost effective. The safety and noticeable effectiveness of these products will far outweigh any initial hesitation you have regarding this mode of delivery.


What makes Zetpil™ Seratone so unique?

What makes the Zetpil™ Seratone product different than any other product on the market is our proprietary blending of oxitriptan (aka: 5-Hydroxytryptophan (5-HTP), with the pure pharmaceutical-grade nutrient co-factors needed to both facilitate the absorption and then the conversion of the herbal source of 5-HTP into serotonin in the brain. 

When this specialized proprietary combination of bioactive ingredients is delivered directly into the body’s bloodstream, the documented clinical responses by patients have resulted in a significant decrease in symptoms related to low serotonin levels. More importantly our product, unlike other 5-HTP-based products, can deliver a therapeutic dosage of this important serotonin precursor directly into the bloodstream, bypassing oral absorption issues and the unwanted side effects (nausea, diarrhea or vomiting) often associated with oral ingestion of 5-HTP (5-Hydroxytryptophan).

Current Treatments for Depression

Current Treatments for Depression

Depression, insomnia, addiction, obsessive or compulsive behavior, PMS, obesity and anxiety have become amongst the most prevalent and frequently recurring disorders in the modern world. These conditions often lead to long-term use of prescription drugs and for most, these battles last a lifetime. 

Selective Serotonin Reuptake Inhibitors (SSRIs hereafter) are approved by the Food and Drug Administration (FDA) to treat depression and are the most commonly prescribed antidepressants. Common examples of SSRIs are citalopram, fluoxetine, paroxetine and sertraline. 

“SSRIs ease depression by affecting naturally occurring chemical messengers (neurotransmitters), which are used to communicate between brain cells. SSRIs block the reabsorption (re-uptake) of the neurotransmitter serotonin in the brain. Changing the balance of serotonin seems to help brain cells send and receive chemical messages, which in turn boosts mood.”
“Most antidepressants work by changing the levels of one or more neurotransmitters. SSRIs are called selective because they seem to primarily affect serotonin, not other neurotransmitters.”

The serotoninergic system is known to modulate mood, emotion, sleep and appetite and thus is implicated in the control of numerous behavioral and physiological functions. Decreased serotoninergic neurotransmission has been proposed to play a key role in the etiology (cause) of depression and associated conditions.

However, despite the widespread use of anti-depressant medications to influence the serotoninergic system, two-thirds (2/3) of patients do not achieve remission or even regain normal quality of life.

Even more discouraging are the new discussions from the pharmaceutical industry admitting that anti-depressants alone do not achieve acceptable success rates, and for those a second pharmaceutical intervention is recommended. Physicians are now prescribing anti-psychotic medicines, in addition to SSRIs, such as aripiprazole (aka: Abilify). Unfortunately adding more drugs only compounds the side effects.

Natural Alternatives

Is there a Safe, Effective and Natural Alternative?

SSRI’s can often have unpleasant side effects especially in prolonged use. A natural alternative is supplementation with L-5-Hydroxytryptophan (5-HTP), the direct serotonin precursor in the brain, which works by providing more of the base raw material the body needs to metabolize serotonin and therefore naturally raise serotonin levels. Unlike SSRI’s, 5-HTP has few known side effects. 

Recent research suggests that Griffonia Seeds P.E., derived from the herb Griffonia Simplicifolia, contain a high concentration of L-5-HTP (5-Hydroxytryptophan), and offers a natural alternative to help manage depressive or compulsive conditions which are often characterized by a common biochemical origin, serotonin deficiency.

5-HTP has been clinically shown to safely and effectively raise serotonin levels in the brain. Serotonin helps support the regulation of endocrine and brain activity responsible for emotion, appetite and sleep/wake cycles and has been proven effective in treating problems such as depression, insomnia, eating disorders, fibromyalgia and migraine headaches. 

5-HTP does not interfere with the normal process of serotonin release or re-absorption. It is not a drug but an amino acid produced naturally by your body from tryptophan. 5-HTP offers an “individualized” approach because the brain inherently self-regulates 5-HTP uptake depending on saturation.

Problems with Oral Products

What are the problems with oral products containing 5-Hydroxytryptophan 5-HTP?

The biggest obstacles with oral delivery of 5-HTP are the side effects (nausea, diarrhea and vomiting), low bioavailability/absorption, and reaching target tissues. First, most oral 5-HTP is prematurely converted in the blood stream to a form of serotonin that cannot cross into the brain where it is needed. Second, much of the ingested 5-HTP is metabolized to serotonin and absorbed in peripheral tissues and adequate amounts do not reach the brain until the peripheral sites are saturated. Third, other nutrient deficiencies will adversely affect the increase of serotonin in your brain. Oral nutrient manufacturers frequently do not formulate 5-HTP products with the necessary co-factors proven to increase serotonin presence in the brain.

Recommended Uses

Supplement Facts



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The use of serotonergic drugs to treat obesity – is there any hope?

Drug Des Devel Ther 2011; 5: 95–109

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Nonpharmacologic Treatment for Fibromyalgia: Patient Education, Cognitive-Behavioral Therapy, Relaxation Techniques, and Complementary and Alternative Medicine

Afton L. Hassett, Psy.D., et al

Rheum Dis Clin North Am. 2009 May; 35(2): 393–407


Psychological stress and fibromyalgia: a review of the evidence suggesting a neuroendocrine link

Anindya Gupta, et al

Arthritis Res Ther. 2004; 6(3): 98–106


Biology and therapy of fibromyalgia. New therapies in fibromyalgia

Lesley M Arnold

Arthritis Res Ther 2006; 8(4): 212


Additional information

Weight 4.1 oz
Dimensions 6 × 1.5 × 9 in