Description
The Zetpil™ Suppository Format
Zetpil™ provides DMSA in a suppository format as an alternative to oral administration. Each suppository is formulated with Zetpil’s proprietary base designed to melt after insertion and provide a convenient, non-oral method of administration. The suppository format eliminates the need to swallow a tablet, capsule or liquid and is designed for convenient at-home use.
Oral supplements can lose effectiveness as they pass through the digestive system due to stomach acid, digestive enzymes, food interactions, first-pass metabolism, and other factors that affect absorption and bioavailability.
Always use the product according to its directions and consult a qualified healthcare professional to determine if this product is appropriate for you.
What Is DMSA?
Meso-2, 3-dimercaptosuccinic acid, or DMSA, is a sulfur-containing organic compound. Chemically, DMSA is a dithiol, which means that it contains two sulfhydryl (also known as S-H) groups. DMSA is also called a succimer, which means it has the chemical structure to combine with lead in the bloodstream. The combination of lead and succimer is then removed from the body by the kidneys. DMSA’s ability to remove the excess lead means less heavy metal buildup/damage to various organs and tissues of the body.
DMSA has been extensively studied for its ability to bind with certain metals. DMSA also has established medical applications that should be managed under the direction of a qualified healthcare professional.
Individuals concerned about possible heavy-metal exposure or toxicity should seek appropriate medical evaluation rather than attempting to diagnose or treat the condition themselves.
Product Information
Serving Size: 1 suppository
Servings Per Package: 25
Each Zetpil™ DMSA Suppository contains: DMSA (2,3-dimercaptosuccinic acid) 260mg, taurine, arginine and a proprietary combination of plant and fruit butters, medium-chain triglycerides, phospholipids, lecithin, magnesium, arrowroot starch, xanthan gum and guar gum.
Storage and Use
Follow the storage instructions provided with the product.
Note- this product loses potency when kept in temperatures below 59 degree Fahrenheit for extended time.
If the product becomes too soft for insertion, place it in the refrigerator for no longer than 10 minutes or until firm.
For rectal use, clear the bowels before insertion when possible. The suppository may be moistened with cool water or used with a personal lubricant to facilitate insertion.
Follow the package directions for proper use.
Warnings
- Keep out of reach of children.
- Consult a qualified healthcare professional before using DMSA.
- Consult your healthcare provider before use if you are pregnant or breastfeeding.
- Consult your healthcare provider before use if you take medications or have a medical condition.
- Do not use if you have a known hypersensitivity to phospholipids or any listed ingredient.
- Do not use if the suppository or packaging is open or damaged.
- Discontinue use and contact your healthcare provider if you experience an adverse reaction.
Due to the nature of this product, suppositories cannot be returned or exchanged.
If you choose to use this product as a rectal suppository, it is highly recommended you attempt to clear your bowels prior to inserting it to avoid premature evacuation. To facilitate insertion it is recommended you moisten the product by passing it under a stream of cool water or use a personal lubricant. When used as a suppository, this product requires 15-20 minutes retention to ensure the complete absorption of the bioactive ingredients. This suppository can be inserted in any position. Although not required, if inserted while lying on one’s side, consider remaining in the supine position for 1-3 minutes following insertion. (Always insert flat end of suppository first).
Individuals that have chosen to take this product as part of a personal nutrient program have overwhelmingly chosen to utilize this product as a rectal suppository. However, this product can also be taken safely by mouth. If one chooses to take this product orally, then this product may be considered a dietary supplement in accordance with current FDA guidelines.
Disclaimer: These statements have not been evaluated by the FDA. This product is a Federal Food, Drug, and Cosmetic Act compliant combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA. In accordance with FDA regulations, when taken orally, this product may be considered a dietary supplement as defined by section 201(ff) of the Act, 21 U.S.C. § 321(ff). Also, this product consists ONLY of a combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA. Therefore, this product cannot be considered a drug as defined in section 201(g)(1) of the Act, 21 U.S.C. § 321(g)(1). This product is not intended to affect the structure or function of the body and is not intended for use in the diagnosis, cure, mitigation, treatment or prevention of disease in man. Any nutritional suggestions and research regarding this product are provided for informational purposes only, and are not intended to diagnose, treat, cure or prevent disease nor should any information provided be used as a substitute for sound medical advice.
References
References
Please visit the National Library of Medicine for further scientific, medical and peer-reviewed research on Heavy Metals, Chelation Therapy and Specific Health Concerns. www.ncbi.com
Chelation: Harnessing and Enhancing Heavy Metal Detoxification—A Review
Margaret E. Sears
The Scientific World Journal; Volume 2013 (2013), Article ID 219840, 13 pages
http://www.hindawi.com/journals/tswj/2013/219840/
Chelation in Metal Intoxication
Swaran J.S. Flora and Vidhu Pachauri
Int J Environ Res Public Health 2010 Jul; 7(7): 2745–2788
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2922724/
Chemical and biological properties of toxic metals and use of chelating agents for the pharmacological treatment of metal poisoning
Maria Stefania Sinicropi
Arch Toxicol 2010 Jul; 84(7):501-20
http://www.ncbi.nlm.nih.gov/pubmed/20386880
Lead induced oxidative stress and its recovery following co-administration of melatonin or N-acetylcysteine during chelation with succimer in male rats
Flora SJ, et al
Cell Mol Biol (Noisy-le-grand) 2004; 50 Online Pub: OL543-51
http://www.ncbi.nlm.nih.gov/pubmed/15555419
Structural, chemical and biological aspects of antioxidants for strategies against metal and metalloid exposure
Swaran J.S. Flora
Oxidative Medicine and Cellular Longevity 2:4, 191-206; September/October 2009
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2763257/
Metals, oxidative stress and neurodegenerative disorders
Mol Cell Biochem 2010 Dec; 345(1-2):91-104
Jomova K, et al
http://www.ncbi.nlm.nih.gov/pubmed/20730621
Advances in metal-induced oxidative stress and human disease
Toxicology 2011 May 10; 283(2-3):65-87
Jomova K, et al
http://www.ncbi.nlm.nih.gov/pubmed/21414382
Advanced Pharmacotherapy Evidenced by Pathogenesis of Autism Spectrum Disorder
Clin Psychopharmacol Neurosci Apr 2014; 12(1): 19–30
Yeon Jung Lee, et al






