Zetpil™ Arginine Plus Suppository



  • Oral arginine stimulates the release of arginase. Arginase decreases the systemic availability of Nitric Oxide (NO) leading to poor vascular health, diabetes complications, and erectile dysfunction.*
  • Research indicates that NO bioavailability is compromised in the aging human heart and vasculature.


Potential of Zetpil Arginine Plus

  • Arginine is a precursor to Nitric oxide (NO) and its production/bioavailability decreases with age.
  • Nitric Oxide is a powerful protector against vascular “traumas” such as inflammation, plaque build-up and blood clots (thrombosis) which lead to cardiovascular diseases. *
  • Endothelial dysfunction has been implicated in age-associated issues such as memory loss, hypertension, stroke, erectile dysfunction, and renal dysfunction.*
  • Arginine increases blood flow which improves wound healing.*
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Out of stock

SKU: 002 Categories: ,


Zetpil™ Suppository Advantage

Zetpil™ delivers nutrition via the rectum with the use of suppositories that have a unique, all- natural formulated base that has revolutionized not only this mode of delivery, but also the ability to obtain nutrients in a far more efficacious method. These suppositories are a result of combining natural ingredients with a non-irritating, rapid melting (5-6 minutes), readily absorbable (superior retention), antioxidant base material (free radical scavenging ability) and delivers the nutrients directly into the bloodstream in less than 20 minutes in a highly effective manner. Oral supplements are exposed to the hazards of stomach acid, digestive enzymes, food-related breakdown, first pass metabolism, and other bioavailability issues in the gastro-intestinal system.

Additionally, many raw materials simply have a very low bioavailability, and only achieve around 10% or less (commonly <1%) absorption rates, even if the patient is in optimal health condition. Compromised health, age, or certain conditions that result in an inability to take oral nutrients often preclude these patient populations from obtaining the necessary nutrition to stay healthy which often exacerbates chronic health issues.

Zetpil™ suppositories are a NOW solution to delivering the necessary nutrients to patients, on a daily basis, that is both easy, comfortable and cost effective. The safety and noticeable effectiveness of these products will far outweigh any initial hesitation you have regarding this mode of delivery.

What makes Zetpil™ Arginine Different?

The Zetpil™ Arginine suppository is truly a revolutionary product. It safely stimulates the production of Nitric Oxide (NO) and may enhance natural Growth Hormone production. Currently, Zetpil™ is the only company in the world that has effectively formulated a product bypassing the issues of oral arginine supplementation. Arginine, and the subsequent production of nitric oxide, is extremely important in vascular and overall health.  However, because of arginine’s inability to be effective when taken orally, the benefits of arginine have been essentially non-existent.   Until now!

One solution appears to be the use of rectal suppositories, and here is why. Research has demonstrated that the oral dosage of arginine may be as high as 11 grams to achieve a therapeutic level of 1,650mgs needed by the body to raise endothelial nitric oxide (eNOS). That dosage is not sustainable for patient compliance. The lower rectal dosage elevates the amount of arginine available for eNOS formation but does so by bypassing the reactive secretion of Arginase.

Thus, instead of 80-85% degradation from Arginase, we get 80-85% absorption and stimulation of beneficial NO levels that enhance endothelial integrity and healing. It also would appear not to trigger the formation of peroxynitrates (free radicals).

Properties of Arginine

Properties of Arginine

Arginine is a semi-essential amino acid and serves many functions in the body. One of its most beneficial actions is as a precursor for Nitric Oxide (NO) synthesis which is formed by a family of enzymes named NO synthases. Nitric oxide is required for normal functions like wound healing, retaining skin moisture, vasodilation (proper regulation of blood flow), regulation of blood pressure, mediating host defense, protection from cardiovascular disease and acts as a neurotransmitter. In fact, nitric oxide deficiency is one of the root causes of cardiovascular disease and contributes to endothelial dysfunction (problems within the blood vessels that damages function).

Why Oral Arginine Can Be Dangerous

Benefits of Arginine

Supplement Facts

Supplement Facts

Each Zetpil™ Arginine Plus contains the following ingredients:

LArginine (a proprietary blend of three of the most active forms of this free amino acid)           444mgs

Magnesium          160mgs

B3/Niacinamide    5mgs

B2/Riboflavin        5mgs

Folinic Acid           1.3mgs

**Note: Each Zetpil™ Arginine suppository is the equivalent of 4,000-5,000 mgs of oral Arginine.   

Serving Size: 1 Suppository
Servings Per Container: 60
Dosage and Use: 2 per day. This product can be taken at any time during the day, before retiring, or as directed by a healthcare professional.
Suppository Base: The base is a proprietary combination of plant and fruit butters, medium chain triglycerides, phospholipids, lecithin, arrow root starch.

This product is contraindicated in individuals with a known hypersensitivity to phospholipids, or any of the listed ingredients.

Due to the nature of the product, suppositories cannot be returned or exchanged.

If you choose to use this product as a rectal suppository, it is highly recommended you attempt to clear your bowels prior to inserting it to avoid premature evacuation. To facilitate insertion it is recommended you moisten the product by passing it under a stream of cool water or use a personal lubricant. When used as a suppository, this product requires 15-20 minutes retention to ensure the complete absorption of the bioactive ingredients. This suppository can be inserted in any position. Although not required, if inserted while lying on one’s side, consider remaining in the supine position for 1-3 minutes following insertion. (Always insert flat end of suppository first).


  • Although safe for children, this product should be kept out of the reach of children.
  • Do not use if the suppositories are open or damaged.
  • As with any nutrient if you are pregnant or breastfeeding, seek the advice of a health care provider before using this product.

Individuals that have chosen to take this product as part of a personal nutrient program have overwhelmingly chosen to utilize this product as a rectal suppository. However, this product can also be taken safely by mouth. If one chooses to take this product orally, then this product may be considered a dietary supplement in accordance with current FDA guidelines.

Disclaimer: These statements have not been evaluated by the FDA. This product is a Federal Food, Drug, and Cosmetic Act compliant combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA. In accordance with FDA regulations, when taken orally, this product may be considered a dietary supplement as defined by section 201(ff) of the Act, 21 U.S.C. § 321(ff).

Also, this product consists ONLY of a combination of naturally derived FDA GRAS (Generally regarded As Safe) herbal, nutraceutical, vitamins, minerals and amino acids products legally sold in the USA. Therefore, this product cannot be considered a drug as defined in section 201(g)(1) of the Act, 21 U.S.C. § 321(g)(1). This product is not intended to affect the structure or function of the body and is not intended for use in the diagnosis, cure, mitigation, treatment or prevention of disease in man. Any nutritional suggestions and research regarding this product are provided for informational purposes only, and are not intended to diagnose, treat, cure or prevent disease nor should any information provided be used as a substitute for sound medical advice.



There are almost 22,000 free peer-reviewed articles on arginine and nitric oxide at the National Library of Medicine.  Please visit the following link to further your understanding. http://www.ncbi.nlm.nih.gov/pmc/?term=arginine%20and%20nitric%20oxide

Mechanisms Involved in the Aging-Induced Vascular Dysfunction

Mariam El Assar, et al

Front Physiol 2012; 3: 132


Aging and the control of human skin blood flow

Front Biosci (Landmark Ed)  2010 Jan 1; 15:718-39

Holowatz LA, et al


Nitric oxide and attenuated reflex cutaneous vasodilation in aged skin

Am J Physiol Heart Circ Physiol 2003 May; 284(5):H1662-7

Holowatz LA, et al


l-Arginine supplementation or arginase inhibition augments reflex cutaneous vasodilatation in aged human skin

J Physiol. 2006 July 15; 574(Pt 2): 573–581

Lacy A Holowatz, et al


The potential of nitric oxide releasing therapies as antimicrobial agents

Virulence May 1, 2012; 3(3): 271–279

David O. Schairer, et al


Development of Novel Arginase Inhibitors for Therapy of Endothelial Dysfunction

Front Immunol 2013; 4: 278

Jochen Steppan, et al



New approaches to the design and discovery of therapies to prevent erectile dysfunction

Expert Opin Drug Discov 2014 Sep 6:1-23

Toque HA, et al


Additional information

Weight 8 oz
Dimensions 6 × 3 × 9 in