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Buyer Beware-

Effective MARKETING or Effective PRODUCTS?

Our emotional desire for more youthful, healthy skin blinds many of us into purchases of products that are not formulated to address the core issues of skin aging, such as decreased skin hormone production, U-V damage to cells, environmental toxins, inflammation and poor vascularity (ie: vessel health). Nobody likes to be lied too. In fact, after people find out that they have been deceived it usually means the end of their relationship with that person or company.

Close examination of current cosmetic and anti-aging products reveals that many are more hype than fact. So called “powerhouse” ingredients touted to be the next great anti-aging breakthrough often lack a scientific basis. When challenged, they claim the ingredients are “secret” or have been altered by a “secret” process. More often than not the “secret” is the products are of poor quality, sub-therapeutic dosages, and formulated with cheap ingredients in fancy bottles charging exorbitant prices.

In order to be effective, a topical formulation must deliver the active ingredients intact at a high enough dosage/ concentration through the skin to actually produce results!  Many times the focus is on the right fragrance, rather than whether it will be effective.

Don’t get us wrong, there are some good products out there- for a lot of money! And there is no doubt a pleasant fragrance and a sensuous “feel” are important. However, Zetpil™ believes the most important criteria are that the product actually works, at a price most anyone can afford.

Zetpil’s anti-aging product line represents the most beneficial anti-aging compounds, proven to address these core issues at the cellular level, at very reasonable prices.

Aging of the Skin

Our skin is a reflection of our overall health. As the largest organ of the body, the skin is often the first part of the body to show the detrimental effects of chronic exposure to environmental pollutants and UV-damage.

However, there is hope! In the past 5 years, there have been numerous clinical studies that have shown that it is possible to delay skin aging and to improve skin conditions through topical administration of nutrients, nutraceuticals and antioxidants which act as free radical scavengers that neutralize and repair the skin.

Free radicals are a natural byproduct of normal cellular respiration/energy production. However when they begin to accumulate in amounts that overwhelm the body’s ability to clear them (i.e. “scavenge” them) these free radicals (highly reactive and unstable molecules) begin to damage the tissue resulting in skin aging  and  DNA damage.  Therefore the body needs an abundance of antioxidants to offset and neutralize the free radicals.  In this way the skin is able to repair and the aging process is slowed. The result is a healthy and youthful appearance of the skin.

 The 3 Biggest Warning Signs an Anti-Aging Product is Ineffective

  1. If a cosmeceutical is marketed with numerous (sometimes almost 30) active ingredients, it should immediately raise a red flag. It is scientifically impossible to include the therapeutic dosage of that many compounds in a formulation, in addition to the necessary permeation enhancers (compounds to increase absorption into the skin) and fragrance.
  2. Fancy packaging and sophisticated marketing using celebrity endorsements has to be paid for and you, the consumer, are paying for both!
  3. When little or no scientific research is provided to substantiate the claims or if it is only generally alluded to (ie: “a study in a journal last year….”), then you should be concerned there is a lack of scientific proof that a particular compound is going to be effective. The cosmeceutical industry is not required to run clinical trials, and therefore scientific research is imperative as the basis for claims.

Effective Marketing does not mean Effective Products

The basic means of misinforming is the manipulation of information that exaggerates or fabricates the potential of an ingredient by implying or outright stating that the ingredient can be adequately absorbed into the body, and the dosage provided in the product is equal to the scientifically-proven dosages in the scientific literature required to exert its effects. In fact, the largest companies are masters at manipulating that very information.

In order for a product to be effective, it must deliver safe and effective dosages of the most bioactive form of the compounds intact, through the skin, to produce a result.

The concepts of bioavailability (the quantity of the ingested dose that is absorbed), mechanism of action (the specific biochemical interaction by which a compound produces its pharmacological effect on specific molecular targets), pharmacokinetics (absorption requirements), and pharmacodynamics (distribution and how a compound functions in the body) are by far the most complex concepts to understand, but they represent what is most commonly manipulated by the cosmetic industry.

Zetpil™ products are all natural, often from totally organic sources. Zetpil™ uses the most bioactive, highest quality ingredients, in conjunction with the latest technological advances for optimal absorption. The result is a line of products that are highly effective as well as very safe.

Zetpil™ prides itself on making money the old fashioned way- by earning it with truth, scientific- and medical-based research, superior products, and the belief that when it comes to people’s health they have an ethical obligation to be honest with their customers. Zetpil™ products work because they were formulated to produce results. Their cost-effectiveness and superiority are self-evident to everyone who uses them.


The Zetpil Line of Anti-Aging Cosmeceutical Products


  • Restores the skin’s levels of this natural hormone precursor and the skin returns to a more youthful appearance*
  • Increases collagen formation, skin hydration and thickness*
  • Reduces the appearance of age spots/discoloration*
  • In combination with Melatonin cream, prevents further UV-induced collagen breakdown in the skin*

Melatonin 25mg TheraCream

  • Improves skin’s firmness and elasticity*
  • Eliminates appearance of fine lines and wrinkles*
  • Repairs photo-damaged skin and protects from further UV-induced damage *
  • Diminishes appearance of age spots*
  • Revitalizes and re-energizes your skin*
  • Reduces appearance of dark circles, crow’s feet and puffiness around your eyes*

NitroBoost Cream

  • moisturizes skin;
  • visibly reduces the signs of spots;
  • improves the vascular integrity of the skin;
  • diminishes the appearance of varicose and spider veins through its wound-healing properties;
  • stimulates protein synthesis promoting thicker skin, and a smoother, wrinkle-free appearance;
  • precursor to creatine which supports the natural skin cell production of collagen and elastin.
* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.


How Much Do We Really Know About Our Favorite Cosmeceutical Ingredients?

Jacquelyn Levin, DO and Saira B. Momin, DO

J Clin Aesthet Dermatol 2010 February; 3(2): 22–41


Intrinsic skin aging: the role of oxidative stress

Poljšak B, et al

Acta Dermatovenerol Alp Panonica Adriat 2012; 21(2):33-6


Differential effects of melatonin as a broad range UV-damage preventive dermato-endocrine regulator

Konrad Kleszczyński, et al

Dermatoendocrinol 2011 Jan-Mar; 3(1): 27–31


Melatonin and human skin aging

Kleszczynski K

Dermatoendocrinol 2012 Jul 1; 4(3):245-52


Skin anti-aging strategies

Ruta Ganceviciene, et al

Dermatoendocrinol 2012 July 1; 4(3): 308–319


On the role of melatonin in skin physiology and pathology

Slominski A, et al

Endocrine 2005 Jul; 27(2):137-48


Therapeutic applications of melatonin

Ifigenia Kostoglou-Athanassiou

Ther Adv Endocrinol Metab2013 February; 4(1): 13–24


Topical melatonin for treatment of androgenetic alopecia

Fischer TW, et al

Int J Trichology 2012 Oct; 4(4):236-45


Attenuation of ultraviolet A-induced alterations in NIH3T3 dermal fibroblasts by melatonin

Rezzani R, et al

Br J Dermatol 2014 Feb; 170(2):382-91


Estrogens and aging skin

Julie Thornton

Dermatoendocrinol 2013 Apr 1; 5(2): 264–270


Basic mechanisms involved in the anti-cancer effects of melatonin (NOTE: Melatonin acting as a SERM and SEEM)

Mediavilla MD, et al

Curr Med Chem 2010; 17(36):4462-81


Free Radicals and Extrinsic Skin Aging

Borut Poljšak and Raja Dahmane

Dermatology Research and Practice

Volume 2012 (2012), Article ID 135206, 4 pages


The circadian control of skin and cutaneous photodamage

Desotelle JA, et al

Photochem Photobiol 2012 Sep-Oct; 88(5):1037-47



Modulation of collagen metabolism by the topical application of dehydroepiandrosterone to human skin

Shin MH, et al

J Invest Dermatol 2005 Feb; 124(2):315-23


Pangenomic changes induced by DHEA in the skin of postmenopausal women

Calvo E, et al

J Steroid Biochem Mol Biol 2008 Dec; 112(4-5):186-93


Modern approach to topical treatment of aging skin

Puizina-Ivić N, et al

Coll Antropol 2010 Sep; 34(3):1145-53



Mechanisms Involved in the Aging-Induced Vascular Dysfunction

Mariam El Assar, et al

Front Physiol 2012; 3: 132


L-Arginine supplementation or arginase inhibition augments reflex cutaneous vasodilatation in aged human skin

Lacy A. Holowatz, et al

J Physiol 574.2 (2006) pp 573–581




Zetpil, Thinking “Outside the Nutritional
Industry Box” to Formulate Products
that Actually Work