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Heart Disease is America’s #1 killer. For years the public has been told that if cholesterol levels are lowered one can appreciably decrease the likelihood of suffering from this insidious disease. However, the media outlets only portray a fraction of the information and nutritional companies looking to capitalize on your fear are selective with the information they disclose.

Zetpil™ doesn’t believe these are ethical practices, and in the end, none of us win. The included video clip is a perfect example of these issues. Although we like the video in many regards, we would like to share it with you and illustrate how our thought process is different, and how we can offer you a potential solution with answers based on science.

If you want to make an appreciable difference in preventing heart disease, we encourage you to follow these steps:

1. Read the “Key Points” below.
2. Watch the video titled “The Cardiac Killer” from the link provided below (take breaks when needed- it’s a lot of information to digest).
3. Return here to see how Zetpil™ is different and that we have solutions for those looking to make an actual difference in their health and their lives.

Video Link:

Video Disclaimers: Zetpil™ did not produce nor contribute to this video. Zetpil™ does NOT believe the video presents ALL the issues surrounding heart disease. Zetpil™ does NOT endorse or support the specific products recommended at the conclusion of the video as they do not mirror the research or the properties of the compounds presented in the video in any appreciable way.


*Statements in quotes are directly from video.

  • “The ‘Cardiac Killer’ is a 21st Century Culprit, and you must arm your body with 21st Century Defenders.”
  • “The solutions of the past will not solve the problems of the present.”
  • “Trying to combat this monster (heart disease) with mere vitamins is much like trying to use a squirt gun to put out a forest fire.”
  • “Key Anti-Inflammatory Nutrients are ESSENTIAL, and virtually non-existent in the bodies of heart attack victims.”
  • Key heart healthy nutrients are naturally depleted with age, beginning as early as 30-45 years old.
  • Cholesterol-lowering drugs (ie: statins) deplete key heart healthy nutrients and are oftentimes counterproductive to the end goal.
  • Our modern environment and food sources have heavily contributed to the prevalence of heart disease in our society; a shift from pre-Industrial Revolution days.



We are different because we don’t care what the “answer” is or if it’s what we wanted to hear. Instead, we let the science guide us, for if we didn’t we would simply be another company selling a product that has no hope of being effective. We refused to waste our time on a fruitless endeavor and instead thought outside the box and found solutions despite the problems!

This video leads the viewer down the right road until the final step, and then detours off a cliff! It represents how something “good” can turn very “bad” in a heartbeat, no pun intended.

They inform us that:

• The establishment’s old hypothesis was wrong;
• The new hypothesis is right and has reliable science and technology to support;
• Our recommendations based on this new information are revolutionary and cutting edge;
• You CANNOT take these new “cutting edge recommendations” orally because of their physical properties; BUT DON’T WORRY ABOUT THAT “TECHNICAL INFORMATION”, because…
• We are different and we have a PILL (oral) that will work even though we just told you we know from the science that it can never work.

So, what is the average person looking to make heart healthy choices to do?

We believe the answer is look to Zetpil™ for viable solutions. Our mission has always been to simply make products that work which are a true reflection of the research and the science of the compounds. The bottom line is this: If you see a product we make, you can be assured it has issues when taken orally. This obviously excludes vitamin, minerals and amino acids, which were developed for those unable to take oral nutrients.

The goal is to make products, with “heavy hitting” active compounds, achieve therapeutic dosages, and positively influence health and disease- period.

What are the Zetpil™ recommendations based on the information in this video?

1. Coenzyme Q10 (CoQ10)

• More absorbable than the less than 10% that is absorbed when taken orally. In fact, one Zetpil™ CoQ10 suppository is equal to approximately 4,000 milligrams of oral CoQ10;
• Formulated with N-Acetyl-Cysteine (NAC) to offer multiple benefits in one administration;
• 450mg of CoQ10 per dosage;
• Ability to approximate therapeutic dosages when delivered rectally versus orally.

2. Melatonin 200mg Cream OR Melatonin Suppository (200mg or 400mg Options)

• Melatonin increases glutathione production (getting the benefit of both compounds with one administration);
• Melatonin can decrease total cholesterol and LDL-cholesterol AS WELL AS increase HDL cholesterol;
• More powerful than Reduced Glutathione;
• Scavenges ALL KNOWN free radicals, including the most deleterious Reactive Nitrogen Species (RNS);
• Crosses all cellular substructures and therefore PROTECTS THE MITOCHONDRIA from oxidative damage;
• Has been clinically shown to decrease blood pressure;
• Is anti-fibrotic (blocks or prevents tissue scarring);
• Helps maintain endothelial function.

3. D-Ribose Powder

• Fatigue, exhaustion, and stressed muscles often occur as a result of depletion of the vital energy molecule called ATP.
• D-ribose supplementation has been clinically shown to boost heart muscle function following ischemia and to aid in function in congestive heart failure patients by providing the energy required for increased activity.*
• Increased ATP levels following D-ribose supplementation can help to reduce the post- exercise muscle pain and fatigue, allowing the maintenance of a more rigorous exercise regimen.

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Please visit for more specific information regarding Zetpil and its products.


Evaluating the Oxidative Stress in Inflammation: Role of Melatonin
Aroha Sánchez , et al
Int. J. Mol. Sci. 2015, 16(8), 16981-17004

Melatonin: An Established Antioxidant Worthy of Use in Clinical Trials
Ahmet Korkmaz, et al
Mol Med 2009 Jan-Feb; 15(1-2): 43–50

Therapeutic applications of melatonin
Ifigenia Kostoglou-Athanassiou
Ther Adv Endocrinol Metab2013 February; 4(1): 13–24

Basic mechanisms involved in the anti-cancer effects of melatonin
Mediavilla MD,et al
Curr Med Chem 2010; 17(36):4462-81

Mechanisms Involved in the Pro-Apoptotic Effect of Melatonin in Cancer Cells
Carmen Rodriguez, et al
Int J Mol Sci 2013 Apr; 14(4): 6597–6613

Melatonin and breast cancer: cellular mechanisms, clinical studies and future perspectives
Stephen G. Grant, et al
Expert Rev Mol Med 2009; 11: e5

Can Melatonin Help Us in Radiation Oncology Treatments?
Ehsan Mihandoost, et al
Biomed Res Int. 2014;2014:578137

Clinical Aspects of Melatonin in the Acute Coronary Syndrome
Alberto Dominguez-Rodriguez, et al
Current Vascular Pharmacology, 2009, 7, 367-373 367

Melatonin and Cardiovascular Disease: Myth or Reality?
Alberto Dominguez-Rodriguez, et al
Rev Esp Cardiol. 2012; 65:215-8. – Vol. 65 Num.03

Peripheral and central effects of melatonin on blood pressure regulation
Pechanova O, et al
Int J Mol Sci 2014 Oct 8; 15(10):17920-37

Melatonin in Alzheimer’s Disease
Li Lin, et al
Int. J. Mol. Sci. 2013, 14, 14575-14593

The anti-apoptotic activity of melatonin in neurodegenerative diseases
Xin Wang
CNS Neurosci Ther 2009 Winter; 15(4): 345–357

Melatonin Therapy in Patients with Alzheimer’s Disease
Daniel P. Cardinali, et al
Antioxidants (Basel) 2014 Jun; 3(2): 245–277
Melatonin: buffering the immune system
Carrillo-Vico A, et al
Int J Mol Sci. 2013 Apr 22; 14(4):8638-83

Melatonin and its influence on immune system
Szczepanik M, et al
J Physiol Pharmacol 2007 Dec; 58 Suppl 6:115-24

Differential effects of melatonin as a broad range UV-damage preventive dermato-endocrine regulator
Konrad Kleszczyński, et al
Dermatoendocrinol 2011 Jan-Mar; 3(1): 27–31

Melatonin and human skin aging
Kleszczynski K
Dermatoendocrinol 2012 Jul 1; 4(3):245-52

On the role of melatonin in skin physiology and pathology
Slominski A, et al
Endocrine 2005 Jul; 27(2):137-48

The glutathione system and its regulation by neurohormone melatonin in the central nervous system
Limón-Pacheco JH, et al
Cent Nerv Syst Agents Med Chem 2010 Dec 1; 10(4):287-97

Protective effect of melatonin against mitochondrial dysfunction associated with cardiac ischemia- reperfusion: role of cardiolipin
Petrosillo G, et al
FASEB J 2006 Feb; 20(2):269-76

Aging and vascular dysfunction: beneficial melatonin effects
Luigi Fabrizio Rodella, et al
Age (Dordr) 2013 Feb; 35(1): 103–115

Melatonin in Mitochondrial Dysfunction and Related Disorders
Venkatramanujam Srinivasan, et al
Int J Alzheimers Dis. 2011; 2011: 326320

Potency of Melatonin in Living Beings
Donchan Choi, et al
Dev Reprod 2013 Sep; 17(3): 149–177

Melatonin protects lung mitochondria from aging
Darío Acuña-Castroviejo, et al
Age (Dordr) 2012 Jun; 34(3): 681–692

Reactive Oxygen Species in Cardiovascular Disease
Koichi Sugamura, John F. Keaney, Jr.
Free Radic Biol Med. 2011 September 1; 51(5): 978–992

Intake of melatonin is associated with amelioration of physiological changes, both metabolic and morphological pathologies associated with obesity: an animal model
Mahmoud R Hussein, et al
Int J Exp Pathol 2007 Feb; 88(1): 19–29

The glutathione system and its regulation by neurohormone melatonin in the central nervous system
Cent Nerv Syst Agents Med Chem 2010 Dec 1; 10(4):287-97
Limón-Pacheco JH, et al


D-Ribose References

Ribose in the Heart
2008, Vol. 5, No. 2, Pages 213-217
James Herrick and John St. Cyr
The benefits of ribose in cardiovascular disease
Pauly DF, Johnson C, St Cyr JA
Med Hypotheses 2003 Feb; 60(2):149-51

The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study
Teitelbaum JE, Johnson C, St Cyr J.
J Altern Complement Med. 2006 Nov; 12(9):857-62

Dermal benefits of topical D-ribose
Shecterle LM, St Cyr JA.
Clin Cosmet Investig Dermatol 2009 Sep 9; 2:151-2

Ribose : A Key to Heart Health and Energy: An interview with John St. Cyr, M.D., Ph.D.
Whole Foods Magazine; January 2005


Coenzyme Q10 (CoQ10) References
**Please note that oral CoQ10 is less than 10% bioavailable (<10%), and unable to achieve the therapeutic dosages required to exert many of these beneficial effects.  One Zetpil CoQ10 suppository is equal to approximately 4,000 milligrams of orally absorbed CoQ10. Please refer back to the discussion under CoQ10 at for more information.

Coenzyme Q10 Therapy
Mol Syndromol Jul 2014; 5(3-4): 187–197
Juan Garrido-Maraver, et al

The relationship between coenzyme Q10, oxidative stress, and antioxidant enzymes activities and coronary artery disease
Lee BJ, et al
Scientific World Journal 2012; 2012:792756

Effect of coenzyme Q10 supplementation on heart failure: a meta-analysis
Am J Clin Nutr Feb 2013; 97(2): 268–275
A Domnica Fotino, et al

Coenzyme Q10 levels are low and associated with increased mortality in post-cardiac arrest patients
Resuscitation Aug 2012; 83(8): 991–995
Michael N. Cocchi, et al

Coenzyme Q10 Decreases Amyloid Pathology and Improves Behavior in a Transgenic Mouse Model of Alzheimer’s Disease
J Alzheimers Dis 2011; 27(1): 211–223
Magali Dumont, et al

Oxidative Stress Correlates with Headache Symptoms in Fibromyalgia: Coenzyme Q10 Effect on Clinical Improvement
PLoS One 2012; 7(4): e35677
Mario D. Cordero, et al

Emulsification using highly hydrophilic surfactants improves the absorption of orally administered coenzyme Q10
Biol Pharm Bull 2013;36(12):2012-7
Sato Y, et al


L-Arginine References

**NOTE: Although arginine and Nitric Oxide are not addressed in the video, we believe they plays an integral role in preventing cardiovascular disease, and we would be remiss if we didn’t include references to that effect.

**NOTE: Oral L-Arginine is CONTRAindicated for those wishing to lower blood pressure, maintain endothelial function, or serve as a potential preventative for heart disease. Please refer back to the discussion under NitroBoost or Arginine Suppositories at for more information.

Mechanisms Involved in the Aging-Induced Vascular Dysfunction
Mariam El Assar, et al
Front Physiol 2012; 3: 132

Aging and the control of human skin blood flow
Front Biosci (Landmark Ed) 2010 Jan 1; 15:718-39
Holowatz LA, et al

L-Arginine supplementation or arginase inhibition augments reflex cutaneous vasodilatation in aged human skin
J Physiol. 2006 July 15; 574(Pt 2): 573–581
Lacy A Holowatz, et al

Development of Novel Arginase Inhibitors for Therapy of Endothelial Dysfunction
Front Immunol 2013; 4: 278
Jochen Steppan, et al

Nitric oxide and the cardiovascular system: cell activation, vascular reactivity and genetic variant
Dias RG, et al
Arq Bras Cardiol 2011 Jan; 96(1):68-75

Nitric oxide and peroxynitrite in health and disease
Pacher P, et al
Physiol Rev 2007 Jan; 87(1):315-424

Zetpil, Thinking “Outside the Nutritional
Industry Box” to Formulate Products
that Actually Work