How to Insert Rectal Suppositories

Rectal suppositories are solid preparations designed for insertion into the rectum.

Proper handling and insertion techniques are important for hygiene and product retention.

The instructions below provide general information for adults. Always follow the labeling for the specific product and any instructions provided by a qualified healthcare professional.

Before Insertion

1. Wash your hands thoroughly with soap and water.
2. Review the product’s storage instructions. Different formulations may have different temperature and handling requirements.
3. If possible, have a bowel movement before insertion to reduce the likelihood of premature evacuation.
4. Remove the suppository from its packaging carefully. Do not use a suppository if its packaging is damaged or the product appears compromised.
5. If necessary, moisten the suppository with cool water or use a small amount of compatible water-soluble lubricant to facilitate insertion. Follow the product’s specific instructions.
6. Disposable medical gloves or a finger cot may be used for hygiene.

Inserting the Suppository

1. Choose a comfortable position. One commonly used method is to lie on your side with the upper knee bent toward your chest.
2. Gently separate the buttocks to expose the rectal area.
3. Using a clean, gloved or protected finger, gently insert the suppository into the rectum according to the manufacturer’s verified instructions, sufficiently past the anal sphincter to help prevent immediate expulsion.
4. Do not force insertion. Stop if significant pain, resistance, or bleeding occurs.
5. Remain lying down briefly if necessary to help retain the suppository.
6. Dispose of used packaging and gloves appropriately.
7. Wash your hands thoroughly after insertion.

After Insertion

Follow the product-specific instructions regarding retention, activity, and administration frequency.

Some suppository bases may soften or melt after insertion. The time required for this to occur does not establish that all active ingredients have been absorbed.

Do not assume that a particular retention period guarantees complete absorption.

If a suppository is expelled shortly after insertion, consult a qualified healthcare professional before administering an additional dose.

Storage and Handling Reminders

• Follow the storage instructions for the specific Zetpil® formulation.
• Do not assume that every suppository should be refrigerated or frozen.
• Avoid exposing products to temperatures or conditions outside their verified storage requirements.
• Keep all products out of reach of children.
• Do not exceed the recommended administration amount or frequency.
• Do not use products by an alternative route unless specifically supported by the product’s instructions and appropriate medical guidance.

Important Safety Information

Consult a qualified healthcare professional before using rectal suppositories, particularly if you have a medical condition, take medications, are pregnant, or are breastfeeding.

Seek medical guidance if insertion causes significant discomfort, bleeding, or other adverse reactions.

These instructions are provided for general educational purposes and do not replace product-specific labeling or professional medical advice.

Reminders

• Store suppositories in the refrigerator or freezer and take out and insert immediately to avoid softening of suppository and to facilitate insertion and retention.
• If the suppository softens, it will reconstitute/harden by putting the softened suppository in the refrigerator or the freezer for approximately 5-10 minutes.
• DO NOT MISS DOSES. FOLLOW YOUR SCHEDULE.
• STORE OUT OF REACH OF CHILDREN.