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Acne (Acne vulgaris) is a dermatological issue that affects between 80-100% of the population with variations in severity. Teenagers and menstruating women are most commonly impacted, often resorting to unproven over-the-counter (OTC) treatments or costly pharmaceutical medications. Many times these treatments are both ineffective and can cause other serious side effects.

Anti-inflammatory and anti-bacterial medications are the most often prescribed treatments. Unfortunately, there has been a significant increase in bacterial resistance in our young population from the repeated use of pharmaceutical medications. It is paramount that we find alternative, natural AND therapeutically-effective options for the treatment of this condition.

There is a robust amount of evidence that identifies the main sources of acne, including dysregulation at the cellular level due to:


  • oxidative stress (insufficient antioxidant protection),
  • inflammation (ie: pro-inflammatory cytokines),
  • bacterial infection,
  • hormonal imbalances, and
  • stress.


It is essential that anti-acne compounds are able to cross all cellular structures and attack the CAUSES of the problem. Many compounds work on the surface, but do not address the problem at the cellular level.


The Zetpil™ Creams penetrate to the cellular level and are the perfect combination of weapons to combat acne.


  1. Zetpil™ Melatonin Cream brings the world’s most powerful antioxidant, anti-inflammatory and anti-bacterial compound to deliver a lethal blow at the main causes of acne.


  1. Zetpil™ NitroBoost Cream:
  • increases collagen and elastin synthesis (arginine),
  • helps maintain appropriate moisture content of the skin (shea and cocoa butters),
  • blocks harmful UVA/UVB rays (Niacinamide), and
  • delivers the B vitamins responsible for healthy skin tone as well as superior acne control (Thiamine).


What makes Zetpil™ different from other nutrition companies?


Zetpil™ is different not only in delivery systems, but they embrace the two biggest issues almost always overlooked by other nutrition companies: bioactive forms of ingredients and therapeutic dosages. Zetpil™ is all about integrity and honesty and every product is formulated with the most active forms of nutrients, the co-factors required for optimal absorption, and at research-proven therapeutic dosages.


  • We do NOT believe in posting pictures of beautiful celebrities who have “cured” their acne (with the most expensive procedures and treatments).
  • We do NOT advocate holistic/homeopathic approaches, which by definition are sub-therapeutic dosages of the active compounds.


Rather, the Zetpil products address and SOLVE the core cellular dysregulation (chemical and biological “misfirings”) that CAUSES acne. Therefore, you can treat existing acne, AND prevent future outbreaks with continued use, without side effects or resistance., The Official Zetpil Website


The information in this focus topic is for educational use only. Do not attempt to self-diagnose or treat any condition. Consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication.


References to Substantiate Claims


Dermatological problems of the puberty

Postepy Dermatol Alergol Jun 2013; 30(3): 178–187

Beata Bergler-Czop, et al


Carrier-based drug delivery system for treatment of acne

Scientific World Journal 2014 Feb 9;2014: 276260

Vyas A, et al


Clinical implications of lipid peroxidation in acne vulgaris: old wine in new bottles

Lipids Health Dis. 2010 Dec 9; 9:141

Bowe WP, et al


Production of superoxide anions by keratinocytes initiates P. acnes-induced inflammation of the skin

PLoS Pathog 2009 Jul; 5(7):e1000527

Grange PA, et al



The Role of Inflammation in the Pathology of Acne

J Clin Aesthet Dermatol Sep 2013; 6(9): 27–35

Emil A. Tanghetti, MD


Hormonal Treatment of Acne in Women

J Clin Aesthet Dermatol Dec 2009; 2(12): 16–22

Tobechi L. Ebede, MD, et al



Melatonin: An Established Antioxidant Worthy of Use in Clinical Trials

Mol Med 2009 Jan-Feb; 15(1-2): 43–50

Ahmet Korkmaz, et al


Melatonin in bacterial and viral infections with focus on sepsis: a review

Recent Pat Endocr Metab Immune Drug Discov 2012 Jan; 6(1):30-9

Srinivasan V, et al



Moisturizers for Acne: What are their Constituents?

J Clin Aesthet Dermatol May 2014; 7(5): 36–44

Leena Chularojanamontri, MD, et al


Not All Acne Is Acne Vulgaris

Dtsch Arztebl Int. Apr 2014; 111(17): 301–312

Harald P Gollnick, Prof. Dr. med



Zetpil, Thinking “Outside the Nutritional
Industry Box” to Formulate Products
that Actually Work